Hepatitis A virus vaccines
AssigneesThe United States of America as represented by the Department of Health and Human Services, SmithKline Beecham Biologicals s.a.
InventorsAnn W. Funkhouser, Suzanne U. Emerson, Robert H. Purcell, Eric D'Hondt
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Abstract
A live hepatitis A virus adapted to growth in MRC-5 cells, which HAV is preferably characterized by suitable attenuation for effective vaccine administration to humans and animals without inactivation, methods for adapting HAV to growth in MRC-5, vaccine compositions and method of vaccinating humans against HAV infection.
Claims7
A DNA molecule encoding a hepatitis A virus adapted to growth in MRC-5 cells, wherein said molecule has a nucleotide sequence according to SEQ ID NO:5.
Dependencies are inferred from the claim text.