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US 6,421,566 B1Granted
Selective dorsal column stimulation in SCS, using conditioning pulses
AssigneeMedtronic, Inc.
InventorJan Holsheimer
Life of this patent
Estimating the term…
Abstract
A system and method is described for preferentially stimulating dorsal column fibers while avoiding stimulation of dorsal root fibers. The invention applies hyperpolarizing pre-pulses and depolarizing pre-pulses to neural tissue, such as spinal cord tissue, through a lead placed over the spinal cord having the electrodes arranged on a line approximately transverse to the axis of the spine. To increase the threshold needed to stimulate dorsal root fibers, the anodal pulse given by each lateral contact of the electrodes has to be preceded by a depolarizing pre-pulse and simultaneously, the central electrode contact gives a hyperpolarizing pre-pulse, thereby reducing the stimulation threshold for the dorsal column fibers to subsequent depolarizing pulses.
Claims23
A method of electrically stimulating neural tissue of the spinal cord comprising the steps of:
- providing a source of electrical pulses;
- providing a first electrode and a second electrode spaced from the first electrode, and an electrical return path;
- connecting the first and second electrodes to the source of electrical pulses;
- placing the first electrode near a patient's spinal cord and placing the second electrode near a dorsal root of the patient's spinal cord;
- applying a depolarizing electrical subthreshold pre-pulse to the tissue through the first electrode and source of electrical pulses whereby the tissue is less susceptible to subsequent electric stimulation;
- applying a depolarizing electrical subthreshold pre-pulse to the tissue through the second electrode and source of electrical pulses whereby the tissue near the second electrode is less susceptible to subsequent electric stimulation;
- and
- applying a subsequent hyperpolarizing electrical pulse to the tissue through the first electrode;
- wherein the step of providing a first electrode and a second electrode spaced from the first electrode includes the step of providing a third electrode spaced from the first electrode opposite the second electrode so that the first electrode is generally between the second and third electrodes and further comprising the step of connecting the third electrode to the source of electrical pulses.
6 more elements
A method of electrically stimulating neural tissue of the spinal cord comprising the steps of:
- providing a source of electrical pulses;
- providing a first electrode and an electrical return path, and providing a second electrode spaced from the first electrode;
- connecting the first and second electrodes to the source of electrical pulses;
- placing the first electrode near a patient's spinal cord;
- applying a depolarizing electrical subthreshold pre-pulse to the tissue through the first electrode and source of electrical pulses whereby the tissue is less susceptible to subsequent electric stimulation;
- and
- applying a subsequent hyperpolarizing electrical pulse to the tissue through the first electrode;
- wherein the step of providing a first electrode and a second electrode spaced from the first electrode includes the step of providing a third electrode spaced from the first electrode opposite the second electrode so that the first electrode is generally between the second and third electrodes and further comprising the step of connecting the third electrode to the source of electrical pulses.
5 more elements
A method of electrically stimulating neural tissue of a spinal cord comprising the steps of:
- providing a source of electrical pulses;
- providing a first electrode and a second electrode spaced from the first electrode, and an electrical return path;
- connecting the first and second electrodes to the source of electrical pulses, placing the first electrode near a patient's spinal cord;
- applying a hyperpolarizing electrical subthreshold pre-pulse to the tissue near the first electrode through the first electrode and source of electrical pulses whereby the tissue near the first electrode is more susceptible to subsequent electric stimulation;
- applying a depolarizing electrical subthreshold pre-pulse to the tissue through the second electrode and source of electrical pulses whereby the tissue near the second electrode is less susceptible to subsequent electric stimulation;
- and
- applying a subsequent depolarizing electrical pulse to the tissue near the first electrode through the first electrode;
- wherein the step of providing a first electrode and a second electrode spaced from the first electrode includes the step of providing a third electrode spaced from the first electrode opposite the second electrode so that the first electrode is generally between the second and third electrodes and further comprising the step of connecting the third electrode to the source of electrical pulses.
5 more elements
The method of claim wherein 6 the step of placing the first electrode near a patient's spinal cord includes the step of placing the third electrode near a dorsal root of the patient's spinal cord wherein the dorsal root near the third electrode is different than the dorsal root near the second electrode.
A method of electrically stimulating neural tissue of a spinal cord comprising the steps of:
- providing a source of electrical pulses;
- providing a first electrode and a second electrode spaced from the first electrode, and an electrical return path;
- connecting the first and second electrodes to the source of electrical pulses;
- placing the first electrode near a patient's spinal cord;
- applying a hyperpolarizing electrical subthreshold pre-pulse to the tissue near the first electrode through the first electrode and source of electrical pulses whereby the tissue near the first electrode is more susceptible to subsequent electric stimulation;
- and
- applying a subsequent depolarizing electrical pulse to the tissue near the first electrode through the first electrode;
- wherein the step of providing a first electrode and a second electrode spaced from the first electrode includes the step of providing a third electrode spaced from the first electrode opposite the second electrode so that the first electrode is generally between the second and third electrodes and further comprising the step of connecting the third electrode to the source of electrical pulses.
5 more elements
A method of electrically stimulating neural tissue of a spinal cord comprising the steps of:
- providing a source of electrical pulses;
- providing a first electrode and a second electrode spaced from the first electrode, and an electrical return path,
- connecting the first and second electrodes to the source of electrical pulses;
- placing the first electrode near a patient's spinal cord;
- applying a hyperpolarizing electrical subthreshold pre-pulse to the tissue near the first electrode through the first electrode and source of electrical pulses whereby the tissue near the first electrode is more susceptible to subsequent electric stimulation;
- and
- applying a subsequent depolarizing electrical pulse to the tissue near the first electrode through the first electrode;
- wherein the step of providing a first and second electrode includes the step of providing a first and second electrode on a single lead.
5 more elements
A method of electrically stimulating neural tissue of a spinal cord comprising the steps of:
- providing a source of electrical pulses having a first and second output;
- providing a lead having a first electrode and a second electrode spaced from the first electrode;
- connecting the lead to the source of electrical pulse so that the first and second electrodes are connected to the first and second outputs, respectively, of the source of electrical pulses;
- placing the lead within a patient's body near a patient's spinal cord so that the first electrode is generally over a midline of the patient's spinal cord;
- applying a hyperpolarizing electrical subthreshold pre-pulse to the tissue near the first electrode through the first electrode of the lead and source of electrical pulses whereby the tissue near the first electrode is more susceptible to subsequent electric stimulation;
- applying a depolarizing electrical subthreshold pre-pulse to the tissue near the second electrode through the second electrode of the lead and source of electrical pulses whereby the tissue near the second electrode is less susceptible to subsequent electric stimulation;
- and,
- applying a subsequent depolarizing electrical pulse to the tissue near the first electrode through the first electrode.
5 more elements
A method of electrically stimulating neural tissue of a spinal cord comprising the steps of:
- providing a source of electrical pulses having a first and a second output;
- providing a lead having a first electrode and a second electrode spaced from the first electrode;
- connecting the lead to the source of electrical pulses so that the first and second electrodes are connected to the first and second outputs, respectively, of the source of electrical pulses;
- placing the lead within a patient's body near a patient's spinal cord so that the first electrode is generally over a midline of the patient's spinal cord;
- applying a hyperpolarizing electrical subthreshold pre-pulse to the tissue near the first electrode through the first electrode of the lead and source of electrical pulses whereby the tissue near the first electrode is more susceptible to subsequent electric stimulation;
- applying a depolarizing electrical subthreshold pre-pulse to the tissue near the second electrode through the second electrode of the lead and source of electrical pulses whereby the tissue near the second electrode is less susceptible to subsequent electric stimulation;
- and,
- applying a subsequent hyperpolarizing electrical pulse to the tissue near the second electrode through the second electrode.
5 more elements
A method of electrically stimulating neural tissue of a spinal cord comprising the steps of:
- providing a source of electrical pulses having a first and a second output;
- providing a lead having a first electrode and a second electrode spaced from the first electrode;
- connecting the lead to the source of electrical pulse so that the first and second electrodes are connected to the first and second outputs, respectively, of the source of electrical pulses;
- placing the lead within a patient's body near a patient's spinal cord so that the first electrode is generally over a midline of the patient's spinal cord;
- applying a hyperpolarizing electrical subthreshold pre-pulse to the tissue near the first electrode through the first electrode of the lead and source of electrical pulses whereby the tissue near the first electrode is more susceptible to subsequent electric stimulation;
- applying a depolarizing electrical subthreshold pre-pulse to the tissue near the second electrode through the second electrode of the lead and source of electrical pulses whereby the tissue near the second electrode is less susceptible to subsequent electric stimulation;
- and,
- applying a subsequent depolarizing suprathreshold electrical pulse to the tissue near the first electrode through the first electrode.
5 more elements
A method of electrically stimulating neural tissue of a spinal cord comprising the steps of:
- providing a source of electrical pulses having a first and a second output;
- providing a lead having a first electrode and a second electrode spaced from the first electrode;
- connecting the lead to the source of electrical pulses so that the first and second electrodes are connected to the first and second outputs, respectively, of the source of electrical pulses;
- placing the lead within a patient's body near a patient's spinal cord so that the first electrode is generally over a midline of the patient's spinal cord;
- applying a hyperpolarizing electrical subthreshold pre-pulse to the tissue near the first electrode through the first electrode of the lead and source of electrical pulses whereby the tissue near the first electrode is more susceptible to subsequent electric stimulation;
- applying a depolarizing electrical subthreshold pre-pulse to the tissue near the second electrode through the second electrode of the lead and source of electrical pulses whereby the tissue near the second electrode is less susceptible to subsequent electric stimulation;
- and,
- applying a subsequent hyperpolarizing suprathreshold electrical pulse to the tissue near the second electrode through the second electrode.
5 more elements
A method of electrically stimulating neural tissue of a spinal cord comprising the steps of:
- providing a source of electrical pulses having a first and a second output;
- providing a lead having a first electrode and a second electrode spaced from the first electrode;
- connecting the lead to the source of electrical pulses so that the first and second electrodes are connected to the first and second outputs, respectively, of the source of electrical pulses;
- placing the lead within a patient's body near a patient's spinal cord so that the first electrode is generally over a midline of the patient's spinal cord;
- applying a hyperpolarizing electrical subthreshold pre-pulse to the tissue near the first electrode through the first electrode of the lead and source of electrical pulse whereby the tissue near the first electrode is more susceptible to subsequent electric stimulation;
- applying a depolarizing electrical subthreshold pre-pulse to the tissue near the second electrode through the second electrode of the lead and source of electrical pulses whereby the tissue near the second electrode is less susceptible to subsequent electric stimulation;
- applying a subsequent depolarizing electrical pulse to the tissue near the first electrode through the first electrode;
- and
- applying a subsequent hyperpolarizing electrical pulse to the tissue near the second electrode through the second electrode.
6 more elements
Dependencies are inferred from the claim text.