Macrolide production
AssigneeBiochemie
InventorsImmaculada Bosch, Victor Centellas, José Diago
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Abstract
A process for the production of azithromycins by methylation of the nitrogen atom in position 9 of the ring structure in 9-deoxo-9a-aza-9a-homoerythromycins in the presence of formaldehyde and in the presence of a reducing agent in non-halogenated solvent; and azithromycin which is free from halogenated organic solvent in a stable anhydrous form; or in the form of a solvate with non-halogenated solvent with the exception of water.
Claims3
In the process for the production of azithromycins by methylation of the nitrogen atom in position 9 of the ring structure in 9-deoxo-9a-aza-9a-homoerythromycins in the presence of formaldehyde and in the presence of a reducing agent, the improvement comprising that methylation is carried out in a non-halogenated solvent which is ethyl acetate, isopropyl acetate or butyl acetate.
Dependencies are inferred from the claim text.