Antimicrobial composition containing photosensitizers articles, and methods of use
Assignee3M Innovative Properties Company
InventorsKevin D. Landgrebe, John J. Stofko, Sheila A. Tesch, John C. Loperfido, David J. Hastings, Thomas J. Packard, Matthew T. Scholz, Linda K. Olson, Kaveh Pournoor, Monserrat R. Lalonde
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Abstract
Polymer compositions and articles incorporating them are provided that possess antimicrobial activity, preferably in both the light and the dark. Such compositions include one or more polymers and one or more photosensitizers.
Claims50
A method of providing an antimicrobial surface, the method comprising combining one or more polymers with one or more photosensitizers to form a surface comprising a hardened polymer composition comprising one or more polymers and one or more photosensitizers, at least one of which is a xanthene photosensitizer, in an amount such that the hardened polymer composition possesses antimicrobial activity in the light and the dark and does not visually colorize white test paper saturated with a 95% by volume ethanol/5% by volume water solution and placed in contact with the hardened polymer composition comprising the one or more photosensitizers under 50-grams/cm2 pressure for 5 minutes;
- wherein at least one of the xanthene photosensitizers has the following formula:
- wherein the negative electric charges are balanced independently with the cations Na+, K+, Li+, H+, or substituted ammonium;
- each A independently represents hydrogen, chlorine, bromine, or iodine;
- and each B independently represents hydrogen, chlorine, bromine, or iodine.
A method of providing an antimicrobial surface, the method comprising combining one or more polymers with one or more photosensitizers to form a surface comprising a hardened polymer composition comprising one or more non-cellulosic polymers and one or more non-covalently bound xanthene photosensitizers in an amount such that the hardened polymer composition possesses antimicrobial activity in the light and the dark and does not visually colorize white test paper saturated with a 95% by volume ethanol/5% by volume water solution and placed in contact with the hardened polymer composition comprising the one or more photosensitizers under 50-grams/cm2 pressure for 5 minutes;
- wherein at least one of the xanthene photosensitizers has the following formula:
- wherein the negative electric charges are balanced independently with the cations Na+, K+, Li+, H+, or substituted ammonium;
- each A independently represents hydrogen, chlorine, bromine, or iodine;
- and each B independently represents hydrogen, chlorine, bromine, or iodine.
A method of limiting the presence of a microorganism, the method comprising contacting the microorganism with a hardened polymer composition comprising one or more polymers and one or more photosensitizers, at least one of which is a xanthene photosensitizer, in an amount such that the hardened polymer composition possesses antimicrobial activity in the light and the dark and does not visually colorize white test paper saturated with a 95% by volume ethanol/5% by volume water solution and placed in contact with the hardened polymer composition comprising the one or more photosensitizers under 50-gram/cm2 pressure for 5 minutes;
- wherein at least one of the xanthene photosensitizers has the following formula:
- wherein the negative electric charges are balanced independently with the cations Na+, K+, Li+, H+, or substituted ammonium;
- each A independently represents hydrogen, chlorine, bromine, or iodine;
- and each B independently represents hydrogen, chlorine, bromine, or iodine.
A method of limiting the presence of a microorganism, the method comprising contacting the microorganism with a hardened polymer composition comprising one or more non-cellulosic polymers and one or more non-covalently bound photosensitizers of the formula:
- wherein the negative electric charges are balanced independently with the cations Na30 , K+, Li+, H+, or substituted ammonium, each A independently represents hydrogen, chlorine, bromine, or iodine;
- and each B independently represents hydrogen, chlorine, bromine, or iodine;
- wherein the hardened polymer composition possesses antimicrobial activity in the light and the dark and does not visually colorize white test paper saturated with a 95%/o by volume ethanol/5% by volume water solution and placed in contact with the hardened polymer composition comprising the one or more photosensitizers under 50-grams/cm2 pressure for 5 minutes.
An article comprising a hardened polymer composition comprising one or more polymers and one or more photosensitizers, at least one of which is a xanthene photosensitizer, wherein the hardened polymer composition possesses antimicrobial activity in the light and the dark and does not visually colorize white test paper saturated with a 95% by volume ethanol/5% by volume water solution and placed in contact with the hardened polymer composition comprising the one or more photosensitizers under 50-grams/cm2 pressure for 5 minutes;
- wherein at least one of the xanthene photosensitizers has the following formula:
- wherein the negative electric charges are balanced independently with the cations Na+, K+, Li+, H+, or substituted ammonium;
- each A independently represents hydrogen, chlorine, bromine, or iodine;
- and each B independently represents hydrogen, chlorine, bromine, or iodine.
An article comprising a hardened polymer composition comprising one or more non-cellulosic polymers and one or more non-covalently bound photosensitizers of the formula:
- wherein the negative electric charges are balanced independently with the cations Na+, K+, Li+, H+, or substituted ammonium;
- each A independently represents hydrogen, chlorine, bromine, or iodine;
- and each B independently represents hydrogen, chlorine, bromine, or iodine;
- wherein the hardened polymer composition possesses antimicrobial activity in the light and the dark and does not visually colorize white test paper saturated with a 95% by volume ethanol/5% water solution and placed in contact with the hardened polymer composition comprising the one or more photosensitizers under a 50-grams/cm2 pressure for 5 minutes.
A stethoscope comprising a hardened polymer composition comprising one or more polymers and one or more photosensitizers wherein the hardened polymer composition possesses antimicrobial activity in the light and the dark and does not visually colorize white test paper saturated with a 95% by volume ethanol/5% by volume water solution and placed in contact with the hardened polymer composition comprising the one or more photosensitizers under 50-grams/cm2 pressure for 5 minutes.
Dependencies are inferred from the claim text.