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US 6,419,954 B1Granted
Tablets and methods for modified release of hydrophilic and other active agents
AssigneeYamanouchi Pharmaceutical Co., Ltd.
InventorsJames S. Chu, Yisong Yang, Joseph A. Fix
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Abstract
The invention provides a tablet and methods for making the tablet comprising a gel-forming material and at least one particle comprising an active agent in contact with a coating material to modify release of the active agent.
Claims53
A tablet comprising:
- at least one particle comprising a hydrophilic active agent in contact with a coating material;
- and
- a gel-forming material comprising:
- a polymer;
- and
- a gelation facilitator agent having a solubility higher than about 0.1 gram/ml in water at a temperature of about 20° C., wherein said at least one particle is blended with said gel-forming material.
3 more elements
A method for producing a tablet, the method comprising:
- (1) mixing a formulation comprising:
- (a) at least one particle comprising a hydrophilic active agent in contact with a coating material;
- (b) a polymer;
- and
- (c) a gelation facilitator agent having a solubility higher than about 0.1 gram/ml in water at a temperature of about 20° C., wherein said at least one particle is blended with said gel-forming material;
- and
- (2) compressing the formulation to produce the tablet.
4 more elements
Dependencies are inferred from the claim text.