Process for preparing chiral (s)-2,3-disubstituted-1-propylamine derivatives
AssigneeSamsung Fine Chemicals Co., Ltd.
InventorsKyoung Rok Roh, Jung Hwan Lee, Dae Il Hwang, Won Jang Lee, Kyung-Il Kim
Life of this patent
Estimating the term…
Abstract
A process for the preparation of chiral (S)-2,3-disubstituted-1-propylamine derivatives, in which a carbonyl group of (S) 3,4-disubstituted-1-butanecarbonyl derivatives is converted to an amine group, and the conversion reaction is performed through Curtius rearrangement or Hoffman rearrangement.
Claims21
A process for preparing chiral (S)-2,3-disubstituted-1-propylamine derivatives expressed in the following formula 1, characterized in that a carbonyl group of chiral (S)-3,4-disubstituted-1-butanecarbonyl derivatives expressed in the following formula 2 is converted to an amine group:
- wherein,
- R1 represents hydrochloric acid salt (H—HCl), sulfuric acid salt (H—H2SO4) or —C(O)OR2;
- R2 represents linear or branched alkyl chain having carbon atoms of 1-10, benzyl or phenyl group;
- X and Y which are same or different, represents a halogen atom, hydroxy group, acetate group, sulfonate group, or in which X and Y are combined to form epoxy group, acetonide group;
- and
- Z represents NH2, NHNH2 or hydroxy group.
Dependencies are inferred from the claim text.