Radioiodinated phospholipid ether analogs and methods of using the same
AssigneeThe Regents of the University of Michigan
InventorsRaymond E. Counsell, Marc A. Longino, Anatoly N. Pinchuk, Mark A. Rampy, Jamey P. Weichert
Life of this patent
Estimating the term…
Abstract
The present invention provides improved radioiodinated phospholipid ether analogs which demonstrate significant tumor avidity and longer plasma half-life than shorter-chain analogs. The radioiodinated phospholipid ether analogs of the present invention provide superior imaging and visualization of neoplastic lesions and tumor-specific cytotoxic cancer therapy.
Claims7
A compound of the general formula:
- where X is a radioactive isotope of iodine;
- n is an integer between 16 and 30;
- Y is selected from the group consisting of H, OH, COOH,
- and OR, and Z is selected from the group consisting of NH2, NR2, and NR3, wherein R is an alkyl or aralkyl substituent.
1-O-[18-(p-Iodophenyl)octadecyl]-1,3-propanediol-3-phosphocholine, wherein iodine is in the form of a radioactive isotope.
1-O-[18-(p-Iodophenyl)octadecyl]-2-O-methyl-rac-glycero-3-phosphocholine, wherein iodine is in the form of a radioactive isotope.
Dependencies are inferred from the claim text.