Mutants of thymidylate synthase and uses thereof
AssigneeSloan-Kettering Institute for Cancer Research
InventorsXinyue Liu-Chen, Youzhi Tong, Joseph R. Bertino, Debabrata Banerjee
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Abstract
The present invention provides a mutated human TS, said mutated synthase differing from wild type TS at amino acid residue 49, amino acid residue 52, amino acid residue 108, amino acid residue 221 or amino acid residue 225. Also provided is cDNA mutated human TSs and novel vectors and host cells and methods of using the mutated human TSs.
Claims11
A mutated human thymidylate synthase (TS), said mutated synthase differing from wild type TS having the amino acid sequence of SEQ ID No. 39 at amino acid residue 49, amino acid residue 52, amino acid residue 108, amino acid residue 221 or amino acid residue 225.
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