A reusable system constructed and arranged for operative association with a removable pumping cartridge, which pumping cartridge providing at least two liquid flow paths therein and including a first component, and at least one membrane disposed on the first component, where the first component and the membrane define a bypass valving chamber, said reusable system comprising:
- a pump housing component constructed and arranged for operative association with said pumping cartridge by coupling to the pumping cartridge;
- a valve actuator to actuate said bypass valving chamber, said actuator disposed adjacent to and in operative association with said bypass valving chamber when said pumping cartridge is coupled to said pump housing;
- and
- a force applicator forming at least a part of said valve actuator, said force applicator constructed and arranged to alternatively (i) apply a force to at least a portion of said membrane to restrict liquid flow through a first liquid flow path through said bypass valving chamber while permitting liquid flow through a second liquid flow path through said bypass valving chamber, (ii) apply a force to at least a portion of said membrane to restrict liquid flow through said second liquid flow path through said bypass valving chamber while permitting liquid flow through said first liquid flow path through said bypass valving chamber, and (iii) apply a force to at least a portion of said membrane to restrict liquid flow through both said first and said second liquid flow paths.