Cyclopentane(ENE)heptenoic or heptenoic acids and derivatives thereof useful as therapeutic agents

A method of treating incontinence, inflammation, immune regulation, disorders of bone metabolism and renal dysfunction which comprises applying to a patient in need of treatment, an amount sufficient to treat such disorders of a compound of formula (II)

• wherein either the cyclopentane(ene) radical or the α or ω chain may be unsaturated and the dotted lines represent the presence or absence of a double bond;
• R1, R2 and R3 are selected from the group consisting of hydroxy, hydrocarbyloxy and heteroatom substituted hydrocarbyloxy wherein said hydrocarbyl radical comprises up to 20 carbon atoms;
• Y represents 2 hydrogen radicals or an oxo radical and X represents a hydroxyl, a hydrocarbylcarboxy, a hydrocarbyloxy, an amino or a mono or dialkyl amino radical y is 0 or an integer of from 1 to 5, Z is a radical selected from the group consisting of halo, nitro, amino, thiol, hydroxy, alkyloxy and alkylcarboxy;
• n is 0 or an integer of from 1 to 3;
• x is 0 or 1 and z is 0 or 1, wherein x is 0, when z is 1 and x is 1, when z is 0 provided, however, at least one of R1, R2 and R3 is a hydrocarbyloxy or heteroatom substituted hydrocarbyloxy radical.