Fast-Dispersing solid oral dosage form containing coarse particles
AssigneeR. P. Scherer Corporation
InventorsRichard Green, Patrick Kearney
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Abstract
This invention is directed to an oral solid, rapidly disintegrating, freeze-dried dosage form containing coarse particles of a pharmaceutically active material which are uncoated or coated with a polymer or lipid material. Preferably, the oral dosage form comprises coarse particles having a size in the range of 50 micron to 400 micron. The oral solid rapidly disintegrating dosage form according to the present invention preferably disintegrates in the oral cavity in less than 10 seconds.
Claims12
A freeze-dried oral solid rapidly disintegrating dosage form comprising coarse particles consisting of a pharmaceutically active material, said coarse particles having a size within the range of 50 μm to 400 μm, which are coated with a polymer or lipid material in a matrix comprising a carrier material and a structure forming agent, wherein said carrier material is selected from the group consisting of water soluble and water-dispersible carrier materials, wherein said dosage form disintegrates in water in less than 10 seconds.
A freeze-dried oral solid rapidly disintegrating dosage form comprising coarse particles consisting of a pharmaceutically active material which are coated with a polymer or lipid material in a matrix comprising a carrier material and a structure forming agent, wherein said carrier material is selected from the group consisting of water soluble and water-dispersible carrier materials, wherein said coarse particles have a size of at least 100 μm.
Dependencies are inferred from the claim text.