High viscosity liquid controlled delivery system and medical or surgical device
AssigneeSouthern BioSystems, Inc.
InventorsJohn W. Gibson, Stacey A. Sullivan, John C. Middleton, Arthur J. Tipton
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Abstract
The present invention relates to novel nonpolymeric compounds and compositions that form liquid, high viscosity materials suitable for the delivery of biologically active substances in a controlled fashion, and for use as medical or surgical devices. The materials can optionally be diluted with a solvent to form a material of lower viscosity, rendering the material easy to administer. This solvent may be water insoluble or water soluble, where the water soluble solvent rapidly diffuses or migrates away from the material in vivo, leaving a higher viscosity liquid material.
Claims58
A liquid composition for the delivery of biologically active substances, comprising:
- a non-water soluble, high viscosity, liquid carrier material comprising a nonpolymeric ester or mixed ester of one or more carboxylc acids, having a viscosity of at least 5,000 cP at 37 C, that does not crystallize neat under ambient or physiological conditions;
- a biological active substance dispersed in the non-water soluble, high viscosity, liquid carrier material;
- wherein when the ester contains an alcohol moiety that is glycerol, the acid moieties do not each consist of a combination of lactic acid moieties and ε-hydroxycaproic acid moieties.
A method of administering a biologically active substance to a plant or animal in need thereof, comprising:
- admistering to the plant or animal a composition comprising:
- a non-water soluble, high viscosity, liquid carrier material comprising a nonpolymeric ester or mixed ester of one or more carboxylic acids, having a viscosity of at least 5,000 cP at 37° C., that does not crystalize neat under ambient or physiological conditions;
- and
- a biologically active substance
- wherein when the ester contains an alcohol moiety that is glycerol, the acid moieties do not each consist of a combination of lactic acid moieties and ε-hydroxycaproic acid moieties.
Dependencies are inferred from the claim text.