Modified internucleoside linkages (II)
AssigneeIsis Pharmaceuticals, Inc.
InventorsSundaramoorthi Swaminathan, Mark Matteucci, Jeff Pudlo, Robert J. Jones
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Abstract
The invention relates to novel modified oligonucleotides, the construction thereof, and their use in oligonucleotide-based therapies. More specifically, the invention is to novel oligonucleotides having modified internucleoside linkages which are resistant to nucleases, having enhanced ability to penetrate cells, and which are capable of binding target oligonucleotide sequences in vitro and in vivo. The modified oligonucleotides of the invention are particularly useful in oligonucleotide-based therapies utilizing the modified oligonucleotides to interrupt protein synthesis or transcription or to otherwise inactivate messenger RNA or double stranded DNA.
Claims5
An oligonucleotide comprising a two, three or four atom modified internucleoside linkage between the 2′ and 5′ position of adjacent nucleosides wherein the modified internucleoside linkage contains at least one carbon atom and at least one nitrogen, oxygen or sulfur atom, provided that no adjacent two or three atoms are all nitrogen, oxygen or sulfur, and wherein the oligonucleotide comprises a conjugate with a label, an intercalator, a drug or a lipophilic group.
Dependencies are inferred from the claim text.