Antisense modulation of human Rho family gene expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsM. Luisa Roberts, Lex M. Cowsert
Life of this patent
Estimating the term…
Abstract
This invention provides compositions and methods for modulating expression of members of the human Rho gene family, which encode low molecular weight GTPases that act as molecular switches in signal transduction. In preferred embodiments, Rho family members include RhoA, RhoB, RhoC, RhoG, Rac1 and cdc42. This invention is also directed to methods for inhibiting hyperproliferation of cells; these methods can be used diagnostically or therapeutically. Furthermore, this invention is directed to treatment of conditions associated with expression of the human Rho family members, particularly in hyperproliferative disorders.
Claims13
An antisense compound 8 to 30 nucleobases in length targeted to an nucleic acid molecule encoding human cdc42 that comprises at least an 8 nucleobase portion of SEQ ID NO:
- 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229 or 230, and wherein said antisense compound inhibits expression of human cdc42.
Dependencies are inferred from the claim text.