Episomally replicating vector, its preparation and use
AssigneeMultiGene Biotech GmbH Biozentrum am Hubland
InventorsArmin Baiker, Jürgen Bode, Christian Fetzer, Hans-Joachim Lipps, Christoph Piechaczek
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Abstract
The present invention relates to stably episomally replicating vectors, comprising at least one scaffold/matrix attached region (S/MAR) and at least one viral or eukaryotic origin of replication (ORI), cells comprising these, processes for their preparation, and their use, in particular as a medicament or diagnostic.
Claims26
A stably episomally replicating vector wherein said vector is retained for over at least 30 generations of cell divisions without the ongoing application of selective pressure, comprising a nucleic acid sequence encoding at least one scaffold/matrix attached region (S/MAR) originating from the 5′ region of the interferon β gene and at least one SV40 or BPV origin of replication (ORI).
Dependencies are inferred from the claim text.