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US 6,410,301 B1Granted
Myxococcus host cells for the production of epothilones
AssigneeKosan Biosciences, Inc.
InventorsBryan Julien, Leonard Katz, Chaitan Khosla
Life of this patent
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Abstract
Recombinant Myxococcus host cell containing recombinant expression vectors containing epothilone polyketide synthase genes can produce epothilones C and D.
Claims6
A recombinant Myxococcus host cell producing epothilones C and D but not epothilones A and B, said host cell containing a recombinant expression vector that contains a nucleotide sequence that encodes the epothilone polyketide synthase (PKS) of Sorangium cellulosum,
- wherein said epothilone PKS is encoded by the epoA, epoB, epoC, epoD, epoE, epoF, and epoK genes of Sorangium cellulosum,
- and wherein said epoK gene is modified to inactivate expression or modified to encode an inactive epoK gene product.
Myxococcus xanthus K111-32.25 (PTA-1700).
Dependencies are inferred from the claim text.