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US 6,407,135 B1Granted
Conjugates of dithiocarbamates with pharmacologically active agents and uses therefor
AssigneeMedinox, Inc.
InventorsChing-San Lai, Tingmin Wang
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AssigneeMedinox, Inc.
InventorsChing-San Lai, Tingmin Wang
Estimating the term…
In accordance with the present invention, there are provided conjugates of nitric oxide scavengers (e.g., dithiocarbamates, or “DC”) and pharmacologically active agents (e.g., NSAIDs). Invention conjugates provide a new class of pharmacologically active agents (e.g., anti-inflammatory agents) which cause a much lower incidence of side-effects due to the protective effects imparted by modifying the pharmacologically active agents as described herein. In addition, invention conjugates are more effective than unmodified pharmacologically active agents because cells and tissues contacted by the pharmacologically active agent(s) are protected from the potentially damaging effects of nitric oxide overproduction induced thereby as a result of the co-production of nitric oxide scavenger (e.g., dithiocarbamate), in addition to free pharmacologically active agent, when invention conjugate is cleaved.
A compound comprising a nitric oxide scavenger covalently linked to a pharmacologically active agent, wherein said covalent linkage is selected from ester, sulfate ester, sulfonate ester, phosphate ester, or carbonate ester.
In the administration of a pharmacologically active agent to a subject for treatrnent of a pathological condition, the improvement comprising covalently attaching a suitable nitric oxide scavenger to said pharmacologically active agent prior to administration of said pharmacologically active agent to said subject.
In the treatment of a subject suffering from a pathological condition by administration thereto of a pharmacologically active agent, the improvement comprising covalently attaching a suitable nitric oxide scavenger to said pharmacologically active agent prior to administration thereof to said subject.
A method for the treatment of a subject afflicted with a pathological condition, said method comprising administering to said subject an effective amount of a modified pharmacologically active agent,
A method for the preparation of a protected form of a pharmacologically active agent, said method comprising covalently attaching a suitable nitric oxide scavenger to said pharmacologically active agent.
A method for reducing the side effects induced by administration of a pharmacologically active agent to a subject, said method comprising covalently attaching a suitable nitric oxide scavenger to said pharmacologically active agent prior to administration to said subject.
A method for enhancing the effectiveness of a pharmacologically active agent, said method comprising covalently attaching a suitable nitric oxide scavenger to said pharmacologically active agent.
Dependencies are inferred from the claim text.