Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
AssigneesUniversity of Iowa Research Foundation, Coley Pharmaceutical GmbH, Ottawa Health Research Institute
InventorsHeather L. Davis, Joachim Schorr, Arthur M. Krieg
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Abstract
The present invention relates generally to adjuvants, and in particular to methods and products utilizing a synergistic combination of immunostimulatory oligonucleotides having at least one unmethylated CpG dinucleotide (CpG ODN) and a non-nucleic acid adjuvant. Such combinations of adjuvants may be used with an antigen or alone. The present invention also relates to methods and products utilizing immunostimulatory oligonucleotides having at least one unmethylated CpG dinucleotide (CpG ODN) for induction of cellular immunity in infants.
Claims11
A composition of a synergistic combination of adjuvants, comprising:
- an effective amount for inducing a synergistic adjuvant response of a combination of adjuvants, wherein the combination of adjuvants includes at least one oligonucleotide containing at least one unmethylated CpG dinucleotide and at least one non-nucleic acid adjuvant.
Dependencies are inferred from the claim text.