Ophthalmic compositions containing galactomannan polymers and borate
AssigneeAlcon Manufacturing, Ltd.
InventorBahram Asgharian
Life of this patent
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Abstract
The present invention is directed to ophthalmic compositions containing a gelling amount of a combination of galactomannan polysaccharides and borates. The compositions gel or partially gel upon administration to the eye. The present invention also discloses methods of topical ophthalmic administration of the compositions of the eye.
Claims37
A topical ophthalmic composition in the form of a liquid, said liquid composition comprising 0.1 to 5% (w/v) guar or a derivative thereof, 0.05 to 5.0% (w/v) of a borate compound, and water, said liquid composition having a pH such that the liquid composition thickens to form a gel or partial gel when one or more drops of the liquid composition are topically administered to the eye.
A sterile ophthalmic pharmaceutical composition, comprising 0.1 to 5% (w/v) of a galactomannan selected from the group consisting of guar and derivatives thereof, 0.05 to 5.0% (w/v) of a borate compound, and water.
A sterile ophthalmic composition according to claim 18, wherein the composition contains hydroxypropyl guar in a concentration of 0.2 to 2.0% (w/v) and boric acid in a concentration of 0.1 to 2.0% (w/v).
A method of delivering a pharmaceutical agent to the eye which comprises topically administering to the eye a sterile ophthalmic composition comprising a pharmaceutically active agent, 0.1 to 5% (w/v) of a galactomannan selected from the group consisting of guar and derivatives thereof, 0.05 to 5% (w/v) of a borate compound, and water.
A sterile ophthalmic pharmaceutical composition useful as an ocular lubricant or artificial tear composition, comprising 0.1 to 3.0% (w/v) of a galactomannan selected from the group consisting of guar and derivatives thereof, 0.1 to 2.0% (w/v) of a borate compound, and water.
Dependencies are inferred from the claim text.