Sulfonamide derivatives and drugs containing the same as the active ingredient

A sulfonamide compound represented by the following formula (1):

• wherein Z represents an imino group, —N(R2)—(CH2)n—, —N(R2)—(CH2)n—N(R3)—, —N(R2)—(CH2)n—O—, —N(R2)—(CH2)n—S—, —N(R2)—(CH2)n—NHSO2—, —N(R2)—CH2CH═CH—, —O(CH2)—N(R3)—, or —N(R2)—(CH2)n—O—CH2—;
• Ar1 represents an aromatic hydrocarbon group, a saturated heterocyclic group or an unsaturated heterocyclic group selected from the group consisting of pyridyl, thienyl, furyl, quinolyl, oxazolyl, thiazolyl, thiadiazolyl, and tetrazolyl.
• Ar2 represents a phenyl group, an alkyl group, a naphthyl group, a quinolyl group, an isoquinolyl group, a thienyl group, or a pyridyl group, which optionally has one through three substituents selected from among a halogen atom, an alkyl group, an alkoxy group, an acetamido group, and a nitro group;
• Ra represents a hydrogen atom, a morpholinoyl group, an alkoxy group, or an aminoalkoxy group;
• Rb represents a hydrogen atom, a halogen atom, an alkyl group, or an alkoxy group;
• Rc represents a hydrogen atom, or an alkyl group or a halogenobenzenesulfonyl group, which optionally has a substituent;
• R1 represents a hydrogen atom, or R1 and R2 together form a trimethylene group;
• R2 represents a hydrogen atom, an alkyl group, a dialkylaminoalkyl group, a benzyl group, a halogenophenyl group, or a halogenobenzenesulfonyl group, R2 and R1 together form a trimethylene group, or R2 and R3 together for an ethanedioyl group or an alkylene group;
• R3 represents a hydrogen atom, an alkyl group, a hydroxyoxalyl group, an alkanoyl group, a sulfonyl group, an alkoxycarbonyl group, or a halogenobenzenesulfonyl group, or R3 and R2 together form an ethanedioyl group or an alkylene group;
• n is a number of 2-4;
• and
• Z is not —N(R2)—CH2—CH═CH— when Ar2 is an isoquinolyl group, or a pharmaceutically acceptable salt thereof.