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US 6,399,389 B1Granted
High throughput screening assay systems in microscale fluidic devices
AssigneeCaliper Technologies Corp.
InventorsJ. Wallace Parce, Anne R. Kopf-Sill, Luc J. Bousse
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Abstract
A method for screening a plurality of compounds is used in conjunction with microfluidic devices for performing high throughput screening assays. A conveyor system is used to transport and dispense libraries of compounds into one or more sample port of a microfluidic device. The microfluidic device accesses the compounds in order to screen large numbers of different compounds for their effects on a variety of chemical and biochemical systems.
Claims13
A method of screening test compounds for an effect on a biochemical system, comprising:
- providing a body structure comprising at least one microchannel, a pipettor extending from said body structure, wherein said pipettor is in fluid communication with said at least one microchannel;
- flowing at least one component of a biochemical system through said at least one microchannel;
- periodically introducing a test compound to contact said component of said biochemical system by transferring said test compound through the pipettor into said at least one microchannel;
- and
- detecting an effect of said test compound on said at least one component of said biochemical system.
2 more elements
Dependencies are inferred from the claim text.