Conditional immortalization of cells
AssigneesReneuron Limited, Ludwig Institute for Cancer Research
InventorParmjit Jat
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Abstract
A recombinant, or genetically engineered, mammalian cell, comprises a conditionally-inducible oncogene and an exogenous polynucleotide encoding the catalytic sub-unit of the telomerase complex. The recombinant cells are useful in therapy, to replace lost or damaged cells.
Claims14
A mammalian cell comprising a conditionally-inducible oncogene and an exogenous polynucleotide encoding the catalytic sub-unit of the telomerase complex.
A recombinant polynucleotide that encodes the catalytic sub-unit of the telomerase complex and a conditionally-inducible oncogene.
A method for immortalising a mammalian cell, comprising incorporating within a proliferating cell a conditionally-inducible oncogene and an exogenous polynucleotide encoding the catalytic sub-unit of the telomerase complex.
Dependencies are inferred from the claim text.