Bioarray chip reaction apparatus and its manufacture
AssigneeAffymetrix, Inc.
InventorsDonald M. Besemer, Virginia W. Goss, James L. Winkler
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Abstract
A package for hybridization includes a substrate and a housing. The substrate has a first surface that includes an array of probes having biological polymers immobilized thereon. The housing includes a fluid cavity constructed and arranged for hybridization of a target to a probe of the probe array located inside the fluid cavity. The housing also includes a bar code.
Claims58
A package for hybridization, comprising:
- a substrate comprising a first surface including a probe array with different probes comprising biological polymers immobilized on said first surface;
- said probe array including a density exceeding 100 different biological polymers per cm2;
- and
- a housing including a fluid cavity constructed and arranged for hybridization of a target to a probe of said probe array, said housing including a bar code.
A package for hybridization, comprising:
- an optically transparent chip comprising a first surface including an array of probes comprising biological polymers immobilized on said first surface;
- and
- a housing including a fluid cavity constructed and arranged for hybridization of a target to a probe of said probe array located inside said fluid cavity, said housing including a bar code and being arranged for use with a detection system.
A probe array deposited on a substrate, comprising:
- a probe array including different probes comprising biological polymers immobilized on said substrate and having a density exceeding 100 different biological polymers per cm2, and
- a bar code.
A package for supporting a probe array, comprising:
- an optically transparent chip comprising an array of different probes including biological polymers, immobilized on a surface of said chip;
- a housing constructed to receive said chip;
- and
- a bar code associated with said chip.
A method of using a probe array, comprising:
- providing an array of probes, comprising biological polymers immobilized on a substrate, having a density exceeding 100 different polymers per cm2;
- providing a bar code associated with said probe array;
- reading said bar code;
- aligning said probe array with a detection system;
- and
- detecting a signal from said probe array.
A method of using a probe array, comprising:
- providing an optically transparent chip comprising a probe array including biological polymers immobilized on a surface and at least some of said polymers hybridized to a target;
- providing a housing, including an alignment structure, said housing being constructed to accommodate said chip and a bar code;
- reading said bar code;
- aligning said housing with a detection system using said alignment structure;
- and
- detecting a signal from said probe array.
Dependencies are inferred from the claim text.