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US 6,395,754 B1Granted
Substituted 2-(2,6-dioxopiperidin-3-yl)- phthalimides and 1-oxoisoindolines and method of reducing TNFα levels
AssigneeCelgene Corporation, et al.
InventorsGeorge W. Muller, David I. Stirling, Roger Shen-Chu Chen
Life of this patent
Estimating the term…
Abstract
Substituted 2-(2,6-dioxopiperidin-3-yl)-phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines reduce the levels of TNFα in a mammal. A typical embodiment is 1-oxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4,5,6,7-tetrafluoroisoindoline.
Claims12
A 2,6-dioxopiperidine selected from the group consisting of (a) a compound of the formula:
- in which:
- one of X and Y is C═O and the other of X and Y is C═O or CH2;
- R6 is hydrogen, alkyl of 1 to 8 carbon atoms, benzyl, chloro, or fluoro;
- R7 is m-phenylene, p-phenylene or —(CnH2n)— in which n has a value of 0 to 4;
- each of R8 and R9 taken independently of the other is hydrogen or alkyl of 1 to 8 carbon atoms, or R8 and R9 taken together are tetramethylene, pentamethylene, hexamethylene, or —CH2CH2X1CH2CH2— in which X1 is —O—, —S— or —NH—;
- and,
- R10 is hydrogen, alkyl of 1 to 8 carbon atoms, or phenyl;
- and,
- (b) the acid addition salts of said compounds which contain a nitrogen atom capable of being protonated.
6 more elements
Dependencies are inferred from the claim text.