Fluorination of ketoamides
AssigneeF2 Chemicals Limited
InventorsRichard Dickinson Chambers, John Hutchinson, Julie Thomson
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Abstract
A process for the preparation of an N,N-disubstituted-2-fluoro-1,3-ketoamide having the formula RCO.CFR′CONR2″ comprises treating an N,N-disubstituted-1,3-ketoamide having the formula RCO.CHR′CONR2″ with elemental fluorine. The groups R, R′ and R″ are independently selected from alkyl, aryl, substituted aryl, cycloalkyl, and substituted cycloalkyl. The group R′ may also be nitro or chlorine.
Claims15
A process for the preparation of an N,N-disubstituted-2-fluoro-1,3-ketoamide having the formula RCO.CFR′CONR2″ which consists essentially of treating an N,N-disubstituted-1,3-ketoamide having the formula RCO.CHR′CON2″ with elemental fluorine, wherein the groups R, R′, and R″ are independently selected from alkyl, aryl, substituted aryl, cycloalkyl, and substituted cycloalkyl and wherein the group R′ may also be hydrogen, nitro or chlorine.
Dependencies are inferred from the claim text.