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US 6,388,124 B2Granted
Dihalo-compound and process for producing vitamin A derivative
AssigneeSumitomo Chemical Company, Limited
InventorsToshiya Takahashi, Shinzo Seko
Life of this patent
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Abstract
There is disclosed a dihalo-compound of formula (1): wherein X1 and X2 represent different halogen atoms, R represents a hydrogen atom or a protective group for a hydroxyl group, and a process for producing vitamin A derivative via a sulfone derivative of formula (5): wherein Ar represents an optionally substituted aryl group, and R represents the same as defined above.
Claims21
A dihalo-compound of formula (1):
- wherein
- X1 and X2 represent different halogen atoms,
- R represents a hydrogen atom or a protective group for a hydroxyl group, and the wavy line denoted by “” means that the stereochemistry relating to the double bond to which said wavy line is bonded is E, Z or a mixture thereof.
A method for producing a sulfone derivative of formula (5):
- wherein
- Ar represents an optionally substituted aryl group,
- R represents a hydrogen atom or a protective group for a hydroxy group, and the wavy line denoted by “” means that the stereochemistry relating to the double bond to which said wavy line is bonded is E, Z or a mixture thereof, which comprises
- reacting a sulfone compound of formula (6):
- wherein Ar is the same as defined above, with a dihalo-compound of formula (1):
- wherein X1 and X2 represent different halogen atoms and the wavy line denoted by “” means that the stereochemistry relating to the double bond to which said wavy line is bonded is E, Z or a mixture thereof, in the presence of a base.
3 more elements
Dependencies are inferred from the claim text.