Preparation method of arbutin intermediates
AssigneesKorea Research Institute of Chemical Technology, Biolano Co., Ltd.
InventorsYeon Soo Lee, Bum Tae Kim, Yong Ki Min, No Kyun Park, Ki Ho Kim, Jae Seob Lee, See Wha Jeoung, Ki Soo Kim
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Abstract
The invention is related to a preparation method of arbutin intermediate (chemical formula I). It is characterized by the glycosylation of hydroquinone or mono-protectected hydroquinone (chemical formula II) with pentaacetyl-β-D-glucose (chemical formula III) in the presence of Lewis acid and base as catalysts. where Ac is acetyl group, R is hydrogen, alkyl or cycloalkyl group with 1 to 10 carbon, or aliphatic or aromatic acyl group with 1 to 10 carbon.
Claims8
A preparation method of pentaacetyl-β-D-arbutine or tetraacetyl-β-D-arbutine with mono-protecting group (chemical formula I) by the β-stereoselective glycosylation of hydroquinone or mono-protected hydroquinone (chemical formula II) with pentaacetyl-β-D -glucose (chemical formula III) in the presence of Lewis acid and base as reaction catalysts.
- where R is hydrogen, alkyl or cycloalkyl group with 1 to 10 carbon, or aliphatic or aromatic acyl group with 1 to 10 carbon.
Dependencies are inferred from the claim text.