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US 6,388,099 B2Granted
Production of 8,8a-dihydroxy-6-deoxyerythronolide B
AssigneeKosan Biosciences, Inc.
InventorRobert McDaniel
Life of this patent
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Abstract
The heterologous expression of the OlePKS in Streptomyces lividans, produces 8,8a-deoxyoleandolide, an aglycone precursor of oleandomycin. The co-expression with DEBS in S. lividans of the P450 monooxygenase OleP produces 8,8a-dihydroxy-6-deoxyerythonolide B and other derivatives that are precursors to important macrolide antibiotics.
Claims15
A compound selected from the group consisting of 8-hydroxy-6-deoxyerythronolide B, 8a-hydroxy-6-deoxyerythronolide B, 8-hydroxy-8,8a-deoxyoleandolide, 8a-hydroxy-8,8a-deoxyoleandolide, 8,8a-dihdroxy-6-deoxyerythronolide B, 8,8a-dehydro-6-deoxyerythronolide B, and 8,8a-anhydrooleandolide.
Dependencies are inferred from the claim text.