Imidazole derivatives

An imidazole derivative of formula (I):

• wherein X is —CH2—(CH2)p—, —O—, ═NH or —S—;
• R1 is phenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, C3-C7-cycloalkyl, C5-C7-cycloalkenyl, C5-C7-cycloalkynyl or a mono- or bicyclic aromatic or partially or fully saturated heterocyclic group with 5 to 10 ring atoms which are carbon atoms and one to three heteroatoms selected from N, O and S;
• wherein the said phenyl, naphthyl,1,2,3,4-tetrahydronaphthyl, C3-C7-cycloalkyl, C5-C7-cycloalkenyl, C5-C7-cycloalkynyl or mono- or bicyclic aromatic or partially or fully saturated heterocyclic group is optionally substituted with one to three substituents selected independently from halogen, —OH, —NH2, halo-C1-C6-alkyl, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-alkoxy, OH—(C1-C6)-alkyl, NH2—(C1-C6)-alkyl and mono- or di(C1-C6-alkyl)amino;
• R2 is H or C1-C6-alkyl;
• R3 is H or C1-C6-alkyl;
• R4 is H or C1-C6-alkyl;
• R5 is H, or R5 and R7 form together a bond;
• each R6 is independently halogen, —OH, —NH2, halo-C1-C6-alkyl, C1-C6-alkyl, C1-C6-alkoxy or OH—(C1-C6)-alkyl;
• R7 is H, OH or C1-C4-alkyl, or R7 and R5 form together a bond;
• each R8 is independently OH, C1-C6-alkyl, halo-C1-C6-alkyl or C1-C6-alkoxy;
• m is 0,1,2 or 3;
• n is 0 or 1;
• p is 0 or 1;
• r is 0 or 1;
• and
• t is 0,1 or 2;
• or a pharmaceutically acceptable ester or salt thereof.