Tetrazolyl-phenyl acetamide glucokinase activators

A tetrazole selected from the group consisting of a compound of the formula:

• wherein one of R1 or R2 is
• and the other is hydrogen, halogen, lower alkyl sulfonyl, perfluoro-lower alkyl, cyano, or nitro;
• R3 is cycloalkyl;
• R4 is —C(O)—NHR6 or a five- or six-membered heteroaromatic ring connected by a ring carbon atom to the amide group shown, which heteroaromatic ring contains from 1 to 3 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen with a first heteroatom being nitrogen adjacent to the connecting ring carbon atom, said heteroaromatic ring being unsubstituted or monosubstituted with halogen at a position on a ring carbon atom other than that adjacent to said connecting carbon atom;
• R5 is lower alkyl, or perfluoro lower alkyl;
• R6 is hydrogen or lower alkyl;
• n is 0 or 1;
• the * represents the asymmetric carbon atom
• and its pharmaceutically acceptable salts.