Process for production of 3-(3-pyridyl)-1-propanol derivatives
AssigneeKaneka Corporation
InventorsAkira Nishiyama, Kazumi Okuro, Kenji Inoue
Life of this patent
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Abstract
A process for producing a 3-(3-pyridyl)-1-propanol derivative of use as a pharmaceutical intermediate expediently with an inexpensive material is provided. The process is concerned with a 3-(3-pyridyl)-1-propanol derivative (3): in the formula, R1 represents an alkyl group of 1 to 20 carbon atoms, aryl group of 6 to 20 carbon atoms or aralkyl group of 7 to 20 carbon atoms, which may be substituted, and comprises reacting a 3-methylpyridine with a strong base to prepare a 3-methylpyridine metal (1): in the formula, M represents lithium, sodium, potassium or a magnesium halide, where the halide is chloride or bromide, and then reacting said metal salt with an epoxy compound (2):
Claims16
A process for producing a 3-(3-pyridyl)-1-propanol derivative (3):
- in the formula, R1 represents an alkyl group of 1 to 20 carbon atoms, aryl group of 6 to 20 carbon atoms or aralkyl group of 7-to-20 carbon atoms, which may be substituted,
- which comprises reacting a 3-methylpyridine with a strong base to prepare a 3-methylpyridine metal salt (1):
- in the formula, M represents lithium, sodium, potassium or a magnesium halide, where the halide is chloride or bromide,
- and then reacting said metal salt with an epoxy compound (2):
- in the formula, R1 is as defined above,
- to give a 3-(3-pyridyl)-1-propanol derivative,
- wherein the 3-methylpyridine is used in molar in excess of said strong base.
Dependencies are inferred from the claim text.