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US 6,388,080 B1Granted
Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
OwnerGrayson Walker Stowell, Robert R. Whittleinventors
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Abstract
Polymorphs Form B, Form C, and amorphous of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone, commonly known as cilostazol, have been identified. These polymorphs may be formed in pure form, in combination with each other, in combination with other polymorphs of cilostazol, or together with other pharmaceutical agents. Processes for preparing these polymorphs, and combinations of these polymorphs, as well as methods of use and unit dosages of these polymorphic forms, and their combinations, are described.
Claims14
A process for preparing Form C of cilostazol, comprising the steps of:
- melting a cilostazol starting material;
- cooling the melted cilostazol;
- and,
- heating the cooled cilostazol sufficient to induce a cold crystallization of Form C of cilostazol.
1 more element
Dependencies are inferred from the claim text.