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US 6,388,074 B2Granted
Process for the preparation of purine derivatives
AssigneeNovartis International Pharmaceutical Ltd.
InventorsGraham Richard Geen, Richard Lewis Jarvest
Life of this patent
Estimating the term…
Abstract
The present invention provides a process for the synthesis of penciclovir and famciclovir by 9-substituting 2-amino-6-chloropurine (ACP) with an appropriate side chain precursor, followed by conversion of the 6-chloro moiety to a hydroxy moiety (i.e. to form a guanine) or hydrogen (to form a 2-aminopurine), respectively.
Claims2
A process for the preparation of i) penciclovir or ii) famciclovir which process comprises:
- i) hydrolysing 9-(4-acetoxy-3-acetoxymethylbut-1-yl)-2-amino-6-chloropurine to give penciclovir;
- or
- ii) reducing 9-(4-acetoxy-3-acetoxymethylbut-1-yl)-2-amino-6-chloropurine to give famciclovir.
A compound known as 9-(4-acetoxy-3-acetoxymethylbutyl)-2-amino-6-chloropurine.
Dependencies are inferred from the claim text.