Human 2-19 protein homologue, z219a
AssigneeZymoGenetics, Inc.
InventorsDarrell C. Conklin, Hal Blumberg
Life of this patent
Estimating the term…
Abstract
The present invention relates to polynucleotide and polypeptide molecules for z219a, a novel member of the human 2-19 protein family. The polypeptides, and polynucleotides encoding them, may be used for detecting human chromosomal abnormalities. The present invention also includes antibodies to the z219a polypeptides.
Claims6
An isolated polynucleotide molecule selected from the group consisting of:
- (a) polynucleotide molecules comprising a nucleotide sequence as shown in SEQ ID NO:1 from nucleotide 194 to nucleotide 823;
- (b) polynucleotide molecules comprising a nucleotide sequence as shown in SEQ ID NO:1 from nucleotide 119 to nucleotide 823;
- and
- (c) polynucleotide molecules complementary over the entire length (a) or (b).
An isolated polynucleotide sequence that comprises nucleotide 1 to nucleotide 705 or nucleotide 76 to nucleotide 705 of SEQ ID NO:8.
A vector comprising the following operably linked elements:
- a transcription promoter;
- a DNA segment comprising a polynucleotide selected from the group consisting of:
- (a) polynucleotide molecules comprising a nucleotide sequence as shown in SEQ ID NO:
- 1 from nucleotide 194 to nucleotide 823;
- (b) polynucleotide molecules comprising a nucleotide sequence as shown in SEQ ID NO:
- 1 from nucleotide 119 to nucleotide 823;
- (c) polynucleotide molecules comprising a nucleotide sequence as shown in SEQ ID NO:8 from nucleotide 1 to nucleotide 705;
- (d) polynucleotide molecules comprising a nucleotide sequence as shown in SEQ ID NO:8 from nucleotide 76 to nucleotide 705;
- and
- (e) polynucleotide molecules complementary over the entire length of (a), (b), (c) or (d);
- and a transcription terminator,
- wherein the promoter is operably linked to the DNA segment, and the DNA segment is operably linked to the transcription terminator.
A DNA construct encoding a fusion protein, the DNA construct comprising:
- a first DNA segment encoding a polypeptide comprising a sequence of amino acid residues 1 (Met) through 25 (Gly) of SEQ ID NO:2;
- and
- a second DNA segment encoding an additional polypeptide,
- wherein the first and second DNA segments are connected in-frame;
- and
- encode the fusion protein.
Dependencies are inferred from the claim text.