Anti-cancer compounds
OwnerJohn M. Stewart, Daniel C. F. Chan +3inventors
InventorsJohn M. Stewart, Daniel C. F. Chan, Lajos Gera, Eunice York, Paul Bunn
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Abstract
The present invention provides compounds useful to inhibit tumor growth and to induce apoptosis. In general, the anti-cancer agents (ACA) are described by the formula: [ACA]n-X [Formula I] wherein X is a linker group having 2-5 functional groups or is absent, n=1, and ACA is selected from the group consisting of Formula II, Formula III, Formula IV, Formula V, and Formula VI, as described herein. Other compounds described herein are defined by the Formula VII, as described herein.
Claims11
The compound of structure:
- 2,3,4,5,6-Pentafluorocinnamoyl-D-Arginine-Arginine-Proline-Trans-4-hydroxyproline-Glycine-α-2-Indanylglycine-Serine-D-α-2-Indanylglycine-Octahydroindole-2-carboxylic acid-Arginine
- or a pharmaceutically acceptable salt thereof.
The compound of the structure:
- 2,3,4,5,6Pentafluorocinnamoyl-Lysine-Lysine-Arginine-Proline-Trans-4-hydoxyproline-Glycine-α-Cylcopentylglycine-Serine-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid-α-Cylcopentylglycine
- or a pharmaceutically acceptable salt thereof.
The compound of structure:
- 2,3,4,5,6-Pentafluorocinnamoyl-D-ε-Nicotinoyllysine-4-(2-pyrazine carboxyl)ornithine Proline-Trans-4-hydroxyproline-Glycine-α-2-Indanylglycine-Serine-D-α-2-Indanylglycine-Octahydroindole-2-carboxylic acid-Arginine
- or a pharmaceutically acceptable salt thereof.
The compound of structure:
- 2,3,4,5,6-Pentafluorocinnamoyl-p-Fluorophenylalanine-Arginine
- or a pharmaceutically acceptable salt thereof.
The compound comprising the structure:
- Dodecanedioyl-(D-Arginine-Pentaflurorphenylalanine-Arginine)2
- or a pharmaceutically acceptable salt thereof.
The compound of structure:
- 2,3,4,5,6-Pentafluorocinnamoyl-O-2,6-Dichlorobenzyltyrosine-4-Amino-2,2,6,6-tetramethylpiperidine
- or a pharmaceutically acceptable salt thereof.
The compound of structure:
- Dodecanedioyl-(D-Arginine-α-2-Indanylglycine-Arginine-4-(Methylamino)-2,2,6,6-tetramethylpiperidine)2
- or a pharmaceutically acceptable salt thereof.
The compound comprising the structure:
- Ethylenediaminetetraacetyl-(O-2,6-Dichlorobenzyltyrosine-4-(Methylamino)-2,2,6,6-tetramethylpiperidine)4
- or a pharmaceutically acceptable salt thereof.
The compound of structure:
- (5-dimethylamino-1-naphthalenesulfonyl-D-Arginine-α-2-Indanylglycine-Arginine)2-1,10-Decanediame
- or a pharmaceutically acceptable salt thereof.
The compound of structure:
- Dodecanedioyl-(D-Arginine-β-2Naphthylalanine-Arginine-4-(methylamino)-2,2,6,6-tetramethylpiperidine)2
- or a pharmaceutically acceptable salt thereof.
The compound of structure:
- Decanedioyl-(-4-Aminocinnamic acid-α-2-Indanylglycine-4-amino-2,2,6,6-tetramethylpiperidine),(-Lysine-D-Arginine-Arginine-Proline-Trans-4-hydroxyproline-Glycine-α-2-Indanylglycine-Serine-D-α-2-Indanylglycine-Octrahydroindole-2-carboxylic acid-Arginine),
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.