Linker binding carriers for organic synthesis, their production and use

A linker binding carrier for organic synthesis represented by the formula:

• —Y—Z—W—(SO2X)m
• wherein
• is a carrier represented by
• wherein
• is a polystyrene carrier,
• X is a leaving group which is
• (i) a halogen atom or
• (ii) a sulfonyloxy group substituted by alkyl or aryl,
• Y is a bond or spacer selected from the group consisting of
• —(CH2)p—, (i)
• —(CH2)q—NR1—(CH2)r—, (ii)
• —(CH2)q—O—(CH2)r—, (iii)
• —(CH2)q—S—(CH2)r—, (iv)
• —(CH2)q—SO—(CH2)r—, (v)
• —(CH2)q—SO2—(CH2)r—, (vi)
• —CH2NH—, (vii)
• wherein p is an integer of 1 to 6,
• q is an integer of 1 to 3,
• r is an integer of 1 to 3 and
• R1 is a C1-6 alkyl group,
• Z is a bivalent group such that
• when Z is a bivalent electron attractive group,
• the bivalent electron attractive group represented by Z is a carbonyl group, a thiocarbonyl group, a sulfonyl group, a sulfinyl group, a carbamoyl group, a thiocarbamoyl group, a halogeno-methene group or a halogeno-ethene group,
• W is an aromatic ring which may be substituted, wherein the aromatic ring is (i) a C6-14 aromatic hydrocarbon or (ii) an aromatic heterocycle containing 1 to 4 hetero atoms selected from the group consisting of an oxygen atom, a sulfur atom and a nitrogen atom or its condensed ring,
• and the C6-14 aromatic hydrocarbon and the aromatic heterocycle or its condensed ring may be substituted by
• (i) a halogen atom,
• (ii) a C1-6 alkyl group which may be substituted by 1 to 3 halogens,
• (iii) a C1-6 alkoxy group which may be substituted by 1 to 3 halogens,
• (iv) a C1-6 alkylthio group which may be substituted by 1 to 3 halogens and
• (v) a hydroxy group,
• when Z is a bivalent non-electron attractive group,
• the bivalent non-electron attractive group represented by Z is a C1-6 alkylene group, C2-6 alkenylene group or C2-6 alkynylene group, which is substituted by hydroxy, amino, carboxyl, nitro, (mono- or di-C1-6 alkyl)amino, C1-6 alkoxy, (C1-6 alkyl)carbonyloxy or a halogen atom,
• W is an aromatic ring which may be substituted by an electron attractive group and may be further substituted
• wherein the aromatic ring W is (i) a C6-14 aromatic hydrocarbon or (ii) an aromatic heterocycle containing 1 to 4 hetero atoms selected from the group consisting of an oxygen atom, a sulfur atom and a nitrogen atom or its condensed ring,
• and the C6-14 aromatic hydrocarbon and the aromatic heterocycle or its condensed ring may be substituted by
• (i) a halogen atom,
• (ii) a C1-6 alkyl group which may be substituted by 1 to 3 halogens,
• (iii) a C1-6 alkoxy group which may be substituted by 1 to 3 halogens,
• (iv) a C1-6 alkylthio group which may be substituted by 1 to 3 halogens and
• (v) a hydroxy group,
• and wherein the electron attractive group substituted on the ring represented by W is a halogen atom, a halogeno-C1-6 alkyl group, a halogeno-C6-14 aryl group, a C1-6 alkylsulfonyl group, a C6-14 aryl sulfonyl group, a C1-6 alkylsulfamoyl group, a C6-14 arylsulfamoyl group, a C1-6 alkylsulfinyl group, a C6-14 arylsulfinyl group, a C1-6 alkoxycarbonyl group, a C6-14 aryloxy-carbonyl group, a carbamoyl group, a thiocarbamoyl group, a carboxyl group, an acyl group, a formyl group, a nitro group or a cyano group,
• and m is 1 or 2,
• or a salt thereof.