Enhanced anti-angiogenic activity of permanently charged derivatives of steroid hormones

A method for treating a medical condition which involves angiogenesis in a subject, which comprises administering to a subject in need of such treatment a therapeutically effective amount of a pharmaceutical composition having anti-angiogenic activity which contains as an active ingredient a therapeutically effective quantity of a compound of the formula (I):

• wherein:
• Y is a non-toxic pharmaceutically acceptable anion;
• DRUG is a radical selected from the group consisting of a steroid agonist or antagonist, a mixed agonist-antagonist, and a partial agonist;
• X is a direct bond or a radical selected from the group consisting of —O—;
• —NH—;
• —NR—, wherein R is an alkyl or aryl group with less than ten carbons;
• —PO3—;
• —S—;
• —SO—;
• and —SO2—;
• R1 and R2 are the same or different and may be a radical selected from the group consisting of H, an alkyl of 1-10 carbon atoms, an arylalkyl of 7-16 carbons, and an aryl;
• R3, R4 and R5 are independently a radical selected from the group consisting of a branched or unbranched, cyclic or noncyclic, alkyl of 1-10 carbon atoms;
• an alkyl of up to 10 carbon atoms substituted by a carboxy, hydroxy, alkoxy, halo, or nitro group;
• a branched or unbranched, cyclic or noncyclic arylalkyl of 7-16 carbon atoms;
• and an aryl;
• and
• n is 0-12.