Method of treating gastrointestinal disorders, particularly colitis
AssigneeArco Chemical Technology, L.P.
InventorsHarry Mazurek, Robert W. Harkins
Life of this patent
Estimating the term…
Abstract
Administration of alkoxylated acyl glycerine (AAG) containing lower carboxylic acid acyl moieties to mammalian subjects results in increase of lower carboxylate concentration, particularly in the colon, and may be used to treat such disorders as simple colitis, ulcerative colitis, divertive colitis, colorectal cancer, and other diseases of the gastrointestinal tract where lower carboxylates are implicated. The AAG encourage patient compliance due to substantially no odor, even when butyric acid acyl groups are employed.
Claims20
An alkoxylated acyl glycerol (AAG) useful for administration to mammalian subjects having a need for increased gastrointestinal lower carboxylate, comprising a compound of the formula
- wherein each n individually is an integer from 1 to 5,
- R is
- wherein x is an integer from 0 to 2, wherein R2 and R3 individually are H or C1-4 lower alkyl, wherein R1 is H or C2-6 lower alkyl;
- one or two of R1 may be a C7-24 alkyl or alkenyl group;
- with the proviso that at least one R1 is C2-6 lower alkyl, the compounds are absorbable and/or digestible in the gastrointestinal tract or associated organs to liberate free carboxylic acid of the formula
- where R4 is C2-6 lower alkyl.
A process for increasing the lower carboxylate content of the gastrointestinal tract of a mammal, comprising administering a lower carboxylate-increasing amount of an alkoxylated acyl glycerol (AAG) comprising:
- wherein each n individually is an integer from 1 to 5,
- R is
- wherein x is an integer from 0 to 2, wherein R1 and R3 individually are H or C1-4 lower alkyl, wherein R1 is H or C1-6 lower alkyl;
- one or two of R1 may be a C7-24 alkyl or alkenyl group;
- with the proviso that at least one R1 is C1-4 lower alkyl, the compounds are absorbable and/or digestible in the gastrointestinal tract or associated organs to liberate free carboxylic acid of the formula
- where R4 is C1-6 lower alkyl.
A method of ameliorating a medical disorder caused by low lower carboxylate availability in the gastrointestinal tract or associated organs or treatable by raising concentration of lower carboxylate in the lower gastrointestinal tract or associated organs, said method comprising administration to a patient exhibiting symptoms of said medical disorder a lower carboxylate increasing amount of an alkoxylated acyl glycerol AAG having the formula:
- wherein each n individually is an integer from 1 to 5,
- R is
- wherein x is an integer from 0 to 2, wherein R2 and R3 individually are H or C1-4 lower alkyl, wherein R1 is H or C1-6 lower alkyl;
- one or two of R1 may be a C7-24 alkyl or alkenyl group;
- with the proviso that at least one R1 is C1-6 lower alkyl, the compounds are absorbable and/or digestible in the gastrointestinal tract or associated organs to liberate free carboxylic acid of the formula
- where R4 is C1-6 lower alkyl.
A method of prophylactsis of the gastrointestinal tract of a mammal against gastrointestinal disorders, comprising administering to said mammal a prophylactic amount of an alkoxylated acyl glycerol (AAG) having the formula:
- wherein each n individually is an integer from 1 to 5,
- R is
- wherein x is an integer from 0 to 2, wherein R2 and R3 individually are H or C1-4 lower alkyl, wherein R1 is H or C1-6 lower alkyl;
- one or two of R1 may be a C7-24 alkyl or alkenyl group;
- with the proviso that at least one R1 is C1-6 lower alkyl, the compounds are absorbable and/or digestible in the gastrointestinal tract or associated organs to liberate free carboxylic acid of the formula
- where R4 is C1-6 lower alkyl.
Dependencies are inferred from the claim text.