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US 6,387,944 B1Granted
Benzo(b)thiepine-1,1-dioxide derivatives, a method for the production thereof, medicaments containing these compounds, and their use
AssigneeAventis Pharma Deutschland GmbH
InventorsWendelin Frick, Alfons Enhsen, Heiner Glombik, Hubert Heuer
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Abstract
The invention relates to substituted benzo(b)thiepine-1,1-dioxide derivatives and to the acid addition salts thereof. The invention relates to compounds of formula (I), wherein R1, R2, R3, R4, R5 and Z have the cited descriptions, to the physiologically compatible salts, to physiologically functional derivatives, and to a method for the production thereof. The compounds are suited, for example, as hypolipidemic agents.
Claims15
A compound of the formula I
- in which
- R1 is methyl, ethyl, propyl, butyl;
- R2 is H, OH, NH2, NH—(C1-C6)-alkyl;
- R3 is an amino acid radical, diamino acid radical, triamino acid radical, tetraamino acid radical, the amino acid radical, diamino acid radical, triamino acid radical or tetraamino acid radical optionally being mono- or polysubstituted by an amino acid protective group;
- R4 is methyl, ethyl, propyl, butyl;
- R5 is methyl, ethyl, propyl, butyl;
- Z is —(C═O)n—C0-C16-alkyl, —(C═O)n—C0-C16-alkyl-NH—, —(C═O)n—C0-C16-alkyl-O—, —(C═O)n—C1-C16-alkyl-(C═O)m, a covalent bond;
- n is 0 or 1;
- m is 0 or 1;
- or its pharmaceutically tolerable salts and physiologically functional derivatives.
7 more elements
Dependencies are inferred from the claim text.