Method of treating disorders related to protease-activated receptors-induced cell activation
AssigneeYung Shin Pharmaceutical Ind. Co., Ltd.
InventorsChe-Ming Teng, Sheng-Chu Kuo, Fang Yu Lee
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Abstract
A method of treating a disorder related to cell activation induced by protease-activated receptors. The method includes administering to a subject in need thereof a compound having a pyrazolyl core; an aryl group, via an via an alkylene linker, bonded to 1-N of the pyrazolyl core; a second aryl group fused at 4-C and 5-C of the pyrazolyl core; and a third aryl group bonded directly to 3-C of the pyrazolyl core.
Claims30
A method of treating a disorder related to protease activated receptor-induced cell activation, comprising administering to a subject, in need thereof a compound having a pyrazolyl core;
- a first aryl group, via an alkylene linker, bonded to 1-N of the pyrazolyl core;
- a second aryl group fused at 4-C and 5-C of the pyrazolyl core;
- and a third aryl group bonded directly to 3-C of the pyrazolyl core;
- wherein each of the three aryl groups, independently, is phenyl, thienyl, furyl, or pyrrolyl, optionally substituted with halo, hydroxy, hydrothio, alkyl, alkoxy, alkylthio, (alkylthio)alkyl, carboxyl, alkoxycarbonyl, (thioalkyl)carbonyl, (alkylthio)carbonyl, aminocarbonyl, hydroxyalkyl, alkoxyalkyl, amino, aminoalkyl, thioalkyl, or alkylenedioxo;
- said compound being in an amount effective for treating the disorder.
Dependencies are inferred from the claim text.