Heterocyclylmethyl-substituted pyrazole derivatives

A 3-Heterocyclyl-substituted pyrazole derivative of the formula (III-I)

• in which
• R42 represents a saturated 6-membered heterocyclic ring having up to 2 heteroatoms from the series consisting of S, N and/or O or represents a 5-membered aromatic or saturated heterocyclic ring having 2 to 3 heteroatoms from the series consisting of S, N and/or O, which can also be bonded via a nitrogen atom and which are optionally substituted up to 3 times in an identical or different manner by formyl, phenyl, mercaptyl, carboxyl, trifluoromethyl, hydroxyl, straight-chain or branched acyl, alkoxy, alkylthio or alkoxycarbonyl having in each case up to 6 carbon atoms, nitro, cyano, halogen, phenyl or straight-chain or branched alkyl having up to 6 carbon atoms, which in its turn can be substituted by hydroxyl, halogen, trifluoromethyl, amino, carboxyl, straight-chain or branched acyl, alkoxy, alkoxycarbonyl or acylamino having in each case up to 5 carbon atoms or by a radical of the formula —OR45, wherein
• R45 denotes straight-chain or branched acyl having up to 5 carbon atoms or a group of the formula —SiR46R47R48, wherein
• R46, R47 and R48 are identical or different and denote aryl having 6 to 10 carbon atoms or alkyl having up to 6 carbon atoms,
• and/or can be substituted by a radical of the formula
• wherein
• a3, b3 and b3′ denote the number 0, 1, 2 or 3,
• R49 denotes hydrogen or straight-chain or branched alkyl having up to 4 carbon atoms,
• c3 denotes the number 1 or 2 and
• R50 and R51 are identical or different and denote hydrogen or straight-chain or branched alkyl having up to 10 carbon atoms, which is optionally substituted by cycloalkyl having 3 to 8 carbon atoms or by aryl having 6 to 10 carbon atoms, which in its turn can be substituted by halogen, or
• denote aryl having 6 to 10 carbon atoms, which is optionally substituted by halogen, or
• denote cycloalkyl having 3 to 7 carbon atoms, or
• R50 and R51, together with the nitrogen atom, form a 5- to 7-membered saturated heterocyclic ring, which can optionally contain a further oxygen atom or a radical —NR52, wherein
• R52 denotes hydrogen, straight-chain or branched alkyl having up to 4 carbon atoms or a radical of the formula
• or denotes benzyl or phenyl, wherein the ring systems are optionally substituted by halogen,
• R43 and R44, including the double bond, form a 5-membered aromatic heterocyclic ring having one heteroatom from the series consisting of N, S and/or O, or a phenyl ring, which are optionally substituted up to 3 times in an identical or different manner by formyl, carboxyl, hydroxyl, amino, straight-chain or branched acyl, alkoxy or alkoxycarbonyl having in each case up to 6 carbon atoms, nitro, cyano, halogen, phenyl or straight-chain or branched alkyl having up to 6 carbon atoms, which in its turn can be substituted by hydroxyl, amino, carboxyl, straight-chain or branched acyl, alkoxy or alkoxycarbonyl having in each case up to 5 carbon atoms,
• and/or are optionally substituted by a group of the formula —S(O)c3NR50′R51′, wherein c3, R50′ and R51′ have the abovementioned meaning of c3, R50 and R51 and are identical to or different from these,
• A3 represents a 5- to 6-membered aromatic or saturated heterocyclic ring having up to 3 heteroatoms from the series consisting of S, N and/or O or phenyl, which are optionally substituted up to 3 times in an identical or different manner by amino, mercaptyl, hydroxyl, formyl, carboxyl, straight-chain or branched acyl, alkylthio, alkyloxyacyl, alkoxy or alkoxycarbonyl having in each case up to 6 carbon atoms, nitro, cyano, trifluoromethyl, azido, halogen, phenyl or straight-chain or branched alkyl having up to 6 carbon atoms, which in its turn can be substituted by hydroxyl, carboxyl, straight-chain or branched acyl, alkoxy or alkoxycarbonyl having in each case up to 5 carbon atoms,
• and/or is substituted by a group of the formula (—CO)d3—NR53R54, wherein
• d3 denotes the number 0 or 1,
• R53 and R54 are identical or different and denote hydrogen, phenyl, benzyl or straight-chain or branched alkyl or acyl having in each case up to 5 carbon atoms,
• or an isomer or salt thereof.