Benzimidazole derivatives
AssigneeMochida Pharmaceutical Co., Ltd.
InventorsKiyoshi Mizuguchi, Nobuo Ohzawa, Yasuhiro Nakai, Kazuyuki Matsuura, Shuhei Ohnishi, Yutaka Kato, Tsutomu Satoh
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Abstract
This invention provides novel benzimidazole derivatives represented by the formula (I); a process for producing the same; a drug containing at least one of such compounds as its active ingredient, in particular, a drug for preventing and/or treating diseases exhibiting eosinophilia, bronchial asthma and allergic diseases; and an enhancer for IFN-γ production, and in particular, an antitumor agent or an antiviral agent based on the action of enhancing the IFN-γ production which exhibits excellent oral bioavailability.
Claims29
A compound represented by the following formula (I)
- (wherein R1 represents hydrogen atom or a straight- or branched-chain alkyl group having 1 to 4 carbon atoms, R2 represents cyano group, hydroxymethyl group, 2-(2-imidazolyl)ethenyl group, a phenyl group substituted by one or two —COOR3 groups, or a group —COOR3 or —CONR4R5, R3 represents hydrogen atom or a straight- or branched-chain alkyl group having 1 to 4 carbon atoms, each of R4 and R5 represents hydrogen atom, an alkyl group having 1 or 2 carbon atoms or a group —CH2COOR6 or —CH(CH2Ph)COOR6, wherein R4 and R5 may be the same or different from each other but, when one of R4 and R5 is a group —CH2COOR6 or —CH(CH2Ph)COOR6, the other one is hydrogen atom, A represents any one of groups selected from the class consisting of —CO—, —CH(OR8)—, —CH2O—, —CH(NHR9)CH2—, —CH═CH— and —CH2CH2—, W represents a group —CH2— or a single bond, Q represents a phenyl group which may be substituted by one hydroxyl group, n is from 0 to 2, R6 represents a straight- or branched-chain alkyl group having 1 to 4 carbon atoms, R7 represents hydrogen atom, hydroxyl group, a halogen atom or a straight- or branched-chain alkoxyl group having 1 to 4 carbon atoms, R8 represents hydrogen atom or acetyl group and R9 represents hydrogen atom, acetyl group, phenylsulfonyl group or a benzoyl group which may be substituted by one methoxy group) or a salt thereof.
An optically active compound represented by the following formula (I)-w
- (wherein R represents hydrogen atom or a lower alkyl group, and * is an asymmetric carbon atom) or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.