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US 6,387,934 B1Granted
2-Cyano-3,5-dihydroxyhex-2-enecarboxamide derivatives
AssigneeAventis Pharma Deutschland GmbH
InventorsWilfried Schwab, Ruth Raiss
Life of this patent
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Abstract
2-Cyano-3,5-dihydroxyhex-2-enecarboxamide derivatives are suitable for the production of pharmaceuticals for the prophylaxis and therapy of diseases or disorders whose course involves increased connective tissue or cartilage degradation.
Claims19
A compound of the formula I
- in any stereoisomeric form, or a salt thereof,
- wherein
- R1 is a hydrogen atom or (C1-C4)-alkyl,
- R2 is pyridyl,
- R3 is
- a) —CF3,
- b) —O—CF3,
- c) —S—CF3,
- d) —OH,
- e) —NO2,
- t) halogen,
- g) benzyl,
- h) phenyl,
- i) —O-phenyl,
- j) a hydrogen atom,
- k) —CN, or
- l) —C-phenyl, mono- or polysubstituted by
- 1) (C1-C4)-alkyl,
- 2) halogen,
- 3) —O—CF3 or
- 4) —O—CH3,
- R4 is
- a) (C1-C4)-alkyl,
- b) halogen, or
- c) a hydrogen atom, and
- n is the integer zero, 1, 2, 3 or 4.
23 more elements
Dependencies are inferred from the claim text.