Imminoribitol PNP inhibitors, preparation thereof and use thereof
AssigneeBiocryst Pharmacueticals, Inc.
InventorsPhilip E. Morris, Jr., John A. Montgomery, Yarlagadda S. Babu
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Abstract
Compounds represented by the formula: wherein A is selected from the group consisting of W is NH2 or H; and each X, Y and Z is individually selected from the group consisting of OH, H and halogen provided at least one of X and Y is H; tautomers, or pharmaceutically acceptable salts thereof; are provided. Compounds of the present invention are useful as inhibitors of PNP and of T-cell proliferation. Compounds of the present invention are useful for treating Cancer. Method for preparing the compounds of the present invention are also provided.
Claims5
Compound represented by the formula:
- wherein A is selected from the group consisting of
- W is NH2 or H;
- each X, Y and Z is independently selected from the group consisting of H, OH and halogen provided that at least one of X and Y is H;
- W is H or NH2;
- a tautomer or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.