Estrogen receptor modulators

A compound having the formula:

• and its pharmaceutically acceptable salts, wherein:
• X3 and X4 are selected independently from the group consisting of nitrogen and oxygen such that if one of X3 and X4 is nitrogen, then the other of X3 and X4 is oxygen to form thereby an isoxazole ring structure;
• X5 is —(X10)n—, wherein n is an integer between 1 and 3 and X10, for each value of n, is selected indenpendently from the group consisting of oxygen, —SOx— where x is and integer between 0 and 2, nitrogen, nitrogen substituted with optionally substitued loweralkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, arylcarbonyl, alkylcarbonyl, aralkylcarbonyl, heteroarylcarbonyl, heteroaralkylcarbonyl, and methylene or methine, each optionally substituted from the group consiting of halo, cyano, nitro, thio, amino, carboxyl, formyl, and optionally substituted loweralkyl, loweralkylcarbonyloxy, arylcarbonyloxy, heteroarylcarbonyloxy, cycloalkylcarbonyloxy, cycloheteroalkylcarbonyloxy, aralkycarbonyloxy, heteroaralkylcarbonyloxy, (cycloalkyl)alkylcarbonyloxy, (cycloheteroalkyl)alkylcarbonyloxy, loweralkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, cycloalkycarbonyl, cycloheteroalkycarbonyl, aralkycarbonyl, heteroaralkylcarbonyl, (cycloalkyl)alkylcarbonyl, (cycloheteroalkyl)alkylcarbonyl, loweralkylaminocarbonyl, arylaminocarbonyl, aralkylaminocarbonyl, heteroarylaminocarbonyl, heteroaralkylaminocarbonyl, loweralkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, cycloalkylcarbonylamino, cycloheteroalkylcarbonylamino, aralkylcarbonylamino, heteroaralkylcarbonylamino, (cycloalkyl)alkylcarbonylamino, (cycloheteroalkyl)alkylcarbonylamino, loweralkylamino, arylamino, aralkylamino, heteroarylamino, heteroaralkylamino, loweralkylsulfonyl, arylsulonyl, heteroarylsuflony, cycloalkylsulfonyl, aralkycarbonylthioooxy, carbonylythio, heteroaralkylcarbonylthio, (cycloalkyloxycarbonylthio, (cycloheteroalkyl)alkylcarbonylthio, loweralkyloxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, cycloalkyloxycarbonyl, cycloheteroalkyloxycarbonyl, aralyoxycarbonyloxloxycarbonyl, heteroaralkyloxycarbony, (cycloalkyl)alkyloxycarbony, (cycloheteroalkyl)alkyloxycarbony, iminoloweralkyl, iminocycloalky, ininocycloheteroalkyl, iminoaralkyl, iminoheteroaralkyl, (cycloalkyl)iminoalky, and (cycloheteroalkyl)iminoalkyl;
• X6-X9 selected independently from the group consisting of oxygen, sulfur, sulfinyl, nitrogen, and optionally substituted methine;
• and
• R4 is selected from the group consisting of optionally substitued loweralkyl, aryl, heteraryl, cycloalky, cycloheteroalkyl, aralkyl, heteraralkyl, (cycloalkyl)alkyl, and (cycloheteroalkyl)alkyl.