Anti-inflammatory uses of manzamines
AssigneeHarbor Branch Oceanographic Institution, Inc.
InventorsAlejandro Mayer, Sarath P. Gunasekera, Shirley A. Pomponi, Susan H. Sennett
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Abstract
The subject invention pertains to compounds which are useful as anti-inflammatory agents and to compositions containing such compounds as active ingredients. The novel uses of the compounds relate to the anti-neurogenic inflammatory properties of the disclosed compounds. Specifically exemplified herein is the use of manzamines A, B, C, D, E, and F, and their salts, analogs, and derivatives.
Claims14
A method of treating inflammation in a human or animal, wherein said method comprises administering to said human or animal an effective amount of a compound, or a salt thereof, wherein said compound has a formula selected from the group consisting of:
- wherein X1, X2, X3, X4, X5, and X6 are, independently, a hydrogen, halogen, hydroxy, lower alkoxy, lower acyloxy, or lower mono or dialkyl amino group;
- R1 is a hydrogen, lower alkyl or lower acyl group;
- R2 is a hydrogen, hydroxy, lower alkoxy or lower acyloxy group;
- wherein X1, X2, X3, X4, X5, and X6 are the same or different and are a hydrogen, halogen, hydroxyl, lower alkoxy, lower acyloxy, thiol, lower alkylthiol, nitro, amino, lower alkylsulfonyl, aminosulfonyl, hydroxy sulfonyl (—SO3H), lower acylamino, lower alkyl, or lower monoalkyl- or dialkyl-amino group;
- R1 and R2 are the same or different and are a hydrogen, lower alkyl, or lower acyl group;
- and Y is a hydrogen, hydroxyl, lower alkoxy, or lower acyloxy group
- wherein R is a hydrogen, halogen, hydroxy, or lower acyloxy group;
- and X is a double bonded oxygen, or is the same or different and is any two of a hydrogen, hydroxy, lower alkyl, lower alkoxy, or lower acyloxy group wherein said lower alkyl, alkoxy, or acyloxy groups have from 1 to about 5 carbon atoms.
Dependencies are inferred from the claim text.