Utilization of pyrimidine derivatives for preventing and treating cerebral ischaemia

A method of preventing or treating cerebral ischemia or strokes in a mammal in need of such treatment comprising administering to said mammal an effective amount of pyrimidine derivatives of the formula I

• where
• A is NH or oxygen,
• B is hydrogen or methyl,
• C is hydrogen, methyl or hydroxyl,
• D is methyl,
• E is
• D and E are together —CH2—CH2—NR1—CH2—, —CH2—NR1—CH2— or —CH2—NR1—CH2—CH2—,
• X is nitrogen,
• Y is CH2, CH2—CH2, CH2—CH2CH2 or CH2—CH,
• Z is nitrogen, carbon or CH, with it also being possible for the bond between Y and Z to be a double bond, n is the number 2, 3, or 4,
• R1 is hydrogen, a C1-C4-alkyl group, an acetyl or benzoyl group, a phenylalkyl C1-C4 radical or phenylalkoxy C2-C5 radical, with the aromatic moiety optionally being substituted by halogen, or C1-C4-alkyl, trifluoromethyl, hydroxyl, C1-C4-alkoxy, amino, cyano or nitro groups, a naphthylalkyl C1-C3 radical, a phenylalkanone C2-C4 radical or a phenyl- or pyridylcarbamoylalkyl C2 radical, with it being possible for the phenyl or pyridyl group to be substituted by halogen, a C1-C3-alkyl group, a methoxy group and by a nitro or amino group,
• R2 is a phenyl, pyridyl, pyrimidinyl or pyrazinyl group which is optionally monosubstituted, disubstituted or trisubstituted by halogen atoms, C1-C4-alkyl or trifluoromethyl, trifluoromethoxy, hydroxyl, C1-C4-alkoxy, amino, monomethylamino, dimethylamino, cyano, thiomethyl or nitro groups and which can optionally be fused to a benzene nucleus which can optionally be monosubstituted or disubstituted by halogen atoms, C1-C4-alkyl or hydroxyl, trifluoromethyl, C1-C4-alkoxy, amino, cyano or nitro groups and which can optionally contain 1 nitrogen atom, or to a 5- or 6-membered ring which can contain 1-2 oxygen atoms, or can be substituted by a phenyl-C1-C2-alkyl- or -alkoxy group, with it being possible for the phenyl radical to be substituted by halogen, or a methyl, trifluoromethyl or methoxy group,
• R3 and R4 are, independently of each other, hydrogen or a C1-C4-alkyl group, or their physiologically tolerated salts.