Method of treating glaucoma and ischemic retinopathy

A method for treating a condition or disorder that can be treated by decreasing intraocular pressure in a mammal, comprising administering to said mammal a therapeutically effective amount of a compound of the formula

• or a pharmaceutically acceptable acid addition salt thereof, wherein
• Ar is benzoisothiazolyl or an oxide or dioxide thereof each optionally substituted by one fluoro, chloro, trifluoromethyl, methoxy, cyano or nitro;
• naphthyl optionally substituted by fluoro, chloro, trifluoromethyl, methoxy, cyano or nitro;
• quinolyl;
• 6-hydroxy-8-quinolyl;
• isoquinolyl;
• quinazolyl;
• benzothiazolyl;
• benzothiadiazolyl;
• benzotriazolyl;
• benzoxazolyl;
• benzoxazolonyl;
• indolyl;
• indanyl optionally substituted by one or two fluoro;
• 3-indazolyl optionally substituted by 1-trifluoromethylphenyl;
• or phthalazinyl;
• n is 1 or 2;
• and
• X and Y together with the phenyl to which they are attached form a cyclic ring system selected from quinolyl;
• 2-hydroxyquinolyl;
• benzothiazolyl;
• 2-aminobenzothiazolyl;
• benzoisothiazolyl;
• indazolyl;
• 2-hydroxyindazolyl;
• indolyl;
• oxindolyl optionally substituted by spirocycloalkyl wherein said cycloalkyl moiety contains from 4 to 7 carbon atoms, or by one to three of (C1-C3)alkyl, or by one of chloro, fluoro or phenyl wherein said phenyl is optionally substituted by one chloro or fluoro;
• benzoxazolyl;
• 2-aminobenzoxazolyl;
• benzoxazolonyl;
• 2-aminobenzoxazolinyl;
• benzothiazolonyl;
• benzoimidazolonyl;
• and benzotriazolyl.