Inhibitors of prenyl-protein transferase

A compound which inhibits farnesyl-protein transferase which is:

• 1-(3 -Trifluoromethoxyphenyl)-4-[1-(4-cyanobenzyl)imidazolylmethyl]-2 -piperazinone
• 1-(2,5-Dimethylphenyl)-4-[1-(4-cyanobenzyl)imidazolylmethyl]-2-piperazinone
• 1-(3-Methylphenyl)-4-[1-(4-yanobenzyl)imidazolylmethyl]-2-piperazinone
• 1-(3-Iodophenyl)4-[1-(4-cyanobenzyl)imidazolylmethyl]-2-piperazinone
• 1-(3-Chlorophenyl)-4-[1-(3-methoxy-4-cyanobenzyl)imidazolylmethyl]-2-piperazinone
• 1-(3-Trifluoromethoxyphenyl)-4-[1-( 3-methoxy-4-cyanobenzyl)imidazolylmethyl]-2-piperazinone
• (R)-5-[(Benzyloxy)methyl]-1-(3-chlorophenyl)4-[1-(4-cyanobenzyl)-imidazolylmethyl]-2-piperazinone
• 1-(3-Chlorophenyl)-4-[1-(2-fluoro-4-cyanobenzyl)-1H-imidazol-5-ylmethyl]piperazin-2-one
• 4-[1-(4-Cyanobenzyl)-1H-imidazol-5-ylmethyl]-1-(3-methylthiophenyl)piperazin-2-one
• 4-[1-(4-Cyanobenzyl)-1H-imidazol-5-ylmethyl]-1-(3,5-dichlorophenyl)piperazin-2-one
• 1-(3-Chlorophenyl)-4-{[1-(4-cyanophenyl) 1-ethyl1-1H-imidazol-5-ylmethyl}piperazin-2-one
• 1-(3-Chloro-4-fluorophenyl)-4-[1-(4-cyanobenzyl)-1H-imidazol-5-ylmethyl]piperazin-2-one
• 4-[1-(4-Cyanobenzyl)-1H-imidazol-5-ylmethyl]-1-(3,5-dimethylphenyl)piperazin-2-one
• (S)-5-Benzyl-4-[3-(4-cyanobenzyl-1-imidazol-5-yl)prop-1-phenyl-2-piperazinone
• 1-(3-Chlorophenyl)4-[1-(4nitrobenzyl)-1H-imidazol-5-ylmethyl]piperazin-2-one
• 4-[1-(4-Cyanobenzyl)-1H-imidazol-5-ylmethyl]-1-(3,5-difluorophenyl)piperazin-2-one or
• 4-[1-(4-Cyanobenzyl)-1H-imidazol-5-ylmethyl]-1-(3,4-difluorophenyl)piperazin-2-one
• or a pharmaceutically acceptable salt or optical isomer thereof.