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US 6,387,889 B1Granted
Medicinal compositions for treating eye diseases
AssigneesYamasa Corporation, Toa Eiyo Ltd.
InventorsKazuki Endo, Toichi Abiru, Tomokazu Hosokawa, Miwa Misawa, Takashi Konno
Life of this patent
Estimating the term…
Abstract
Medicinal compositions for treating eye diseases which contain as the active ingredient 2-alkynyladenosine derivatives having an acetylene union at the 2-position of adenine base. Having a long-lasting and remarkable effect of lowering ocular tension, these compositions are useful as remedies for eye diseases accompanying increased ocular tension or optic nerve failures, such as glaucoma and hypertonia oculi.
Claims18
A method for lowering ocular tension, comprising:
- administering to a subject in need thereof an effective amount of a compound of formula (1):
- in free form or in pharmaceutically acceptable acid addition salt form,
- wherein X represents a C4 to C6 hydrocarbon;
- a C4 hydrocarbon substituted with phthalimidyl;
- or a C1 to C6 hydrocarbon substituted with hydroxy, hydroxyphenyl, a C2 to C8 alkoxy, a C6 cycloalkoxy, or a C5 to C6 cycloalkyl, and
- Y represents a hydroxy substituted methyl or hydroxy substituted methyl carboxamide.
3 more elements
A method for treating glaucoma, comprising:
- administering to a subject in need thereof an effective amount of a compound of formula (1):
- in free form or in pharmaceutically acceptable acid addition salt form,
- wherein X represents a C4 to C6 hydrocarbon, a C4 hydrocarbon substituted with phthalimidyl;
- a C1, to C6 hydrocarbon substituted with hydroxy, hydroxyphenyl, a C2 to C8 alkoxy, a C6 cycloalkoxy, or a C5 to C6 cycloalkyl, and
- Y represents a hydroxy substituted methyl or hydroxy substituted methyl carboxamide.
2 more elements
A method for treating ocular hypertonia, comprising:
- administering to a subject in need thereof an effective amount of a compound of formula (1):
- in free form or in pharmaceutically acceptable acid addition salt form,
- wherein X represents a C4 to C6 hydrobon, a C4 hydrocarbon substituted with phthalimidyl;
- a C1 to C6 hydrocarbon substituted with hydroxy, hydroxyphenyl, a C2 to C8 alkoxy, a C6 cycloalkoxy, or a C5 to C6 cycloalkyl, and
- Y represents a hydroxy substituted methyl or hydroxy substituted methyl carboxamide.
2 more elements
Dependencies are inferred from the claim text.